CAS 1293990-73-4, Cat. No EN300-33233409
Reagent for amination
O-Pivaloyl hydroxylammonium triflate (PONT) is an electrophilic aminating reagent1 used to introduce unprotected amino groups onto a variety of substrates, such as alkenes, arenes2, and thiols. It improves step efficiency and atom economy by avoiding the need for protection group manipulations. The reagent is bench-stable, easy to scale up, and facilitates reactions under mild conditions. The reagent is widely applied in catalytic amination reactions, allowing the synthesis of primary, secondary, and tertiary amines.
Synonyms: O-pivaloylhydroxylamine triflic acid; O-pivaloylhydroxylamine trifluoromethanesulfonate; PONT; O-pivaloyl hydroxylammonium triflate
Selected publications
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The Advent of Electrophilic Hydroxylamine-Derived Reagents for the Direct Preparation of Unprotected Amines.
Gasser V.; Makai S.; Morandi B. Chemical Communications 2022, 58 (72), 9991–10003. DOI: 10.1039/D2CC02431D
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Selective Carbon‐Carbon Bond Amination with Redox‐Active Aminating Reagents: A Direct Approach to Anilines.
Qiu X.; Wang Y.; Su L.; Jin R.; Song S.; Qin Q.; Li J.; Zong B.; Jiao N. Chin J Chem 2021, 39 (11), 3011–3016. DOI: 10.1002/cjoc.202100430