CAS 1624625-77-9, Cat. No EN300-39847676
Reagent for trifluoromethoxylation
N-Trifluoromethoxyphthalimide is a recently introduced trifluoromethoxylating reagent of various alkyl electrophiles1. The reagent is a stable solid, that releases a OCF3 anion under mild reaction conditions. The susceptible to nucleophilic trifluoromethoxylation alkyl electrophiles include halogens and pseudohalogen (e.g. OTs and OMs) groups. The transformation shows good functional tolerance and maintains a routine procedure.
Synonyms: 2-(trifluoromethoxy)isoindoline-1,3-dione; 2-(trifluoromethoxy)isoindole-1,3-dione
Selected publication
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N-Trifluoromethoxyphthalimide: A Shelf-Stable Reagent for Nucleophilic Trifluoromethoxylation.
Yuan W.; Tong C.; Xu X.; Qing F. J Org Chem 2023, 88 (7), 4434–4441. DOI: 10.1021/acs.joc.2c03031