CAS 1211592-48-1, Cat. No EN300-26983799
Reagent for synthesis of β‑keto Weinreb amides
N-Methoxy-N-methylcyanoformamide (MMC) is a highly reactive carbamoylating reagent developed for the efficient synthesis of β-keto Weinreb amides and unsymmetrical ketones1. This reagent enables one-pot transformations from lithium enolates, organolithium species, and Grignard reagents to target compounds. Its scope includes substrates such as aryl ketones, enones, lactones, and saturated aliphatic ketones. MMC is a colorless oil that is stable under inert, anhydrous conditions and should be stored below 0°C to prevent degradation.
Synonyms: methoxy(methyl)carbamoyl cyanide; N-methoxy-N-methylcarbonocyanidic amide; carbamoyl cyanide
Selected publication
-
N-Methoxy-N-Methylcyanoformamide, a Highly Reactive Reagent for the Formation of β-Keto Weinreb Amides and Unsymmetrical Ketones.
Nugent J.; Schwartz B. Org Lett 2016, 18 (15), 3834–3837. DOI: 10.1021/acs.orglett.6b01844