N-(Diethylcarbamoyl)-N-methoxyformamide

CAS 146039-03-4, Cat. No EN300-7385578
Reagent for N-formylation

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N-(Diethylcarbamoyl)-N-methoxyformamide is a formylating reagent known for its exceptional chemoselectivity towards primary amines¹. It selectively reacts with primary amines while remaining unreactive to alcohol and secondary amine groups in the substrate. The procedure is straightforward, conducted at ambient temperature, and normally completed within a few hours with high yields. The reagent is bench-stable, easy to handle, and persistent in hydroxylic solvents for a durable time, making it a practical choice for various applications.

Synonyms: 1,1-diethyl-3-formyl-3-methoxyurea; N,N-diethyl-N'-formyl-N'-methoxyurea