CAS 16141-78-9, Cat. No EN300-7436301
Reagent for HWE olefinations
Methyl 2-(dimethyl phosphono)-2-methoxyacetate is a stabilized phosphonate ester used in Horner–Wadsworth–Emmons (HWE) olefinations1. It reacts with aldehydes or ketones under basic conditions to give α,β-unsaturated esters with high E-selectivity. The reagent is stable, easy-to-handle, and compatible with aromatic, aliphatic, and heteroaromatic aldehydes, tolerating both electron-rich and electron-poor substituents.
Synonyms: methyl 2-dimethoxyphosphoryl-2-methoxy-acetate; methyl 2-(dimethoxyphosphoryl)-2-methoxyacetate; methyl (dimethoxyphosphoryl)(methoxy)acetate; methyl 2-dimethoxyphosphoryl-2-methoxyacetate
Selected publication
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Nonoxidative Sequence for the Preparation of 1,2-Diketone Derivatives Using Aldehyde and Organometallic Building Blocks.
Pudner, G. L.; Camp, I.; Scheerer, J. R. A Journal of Organic Chemistry 2022, 87 (12), 8213–8222. DOI: 10.1021/acs.joc.2c00439