CAS 99128-10-6, Cat. No EN300-51865873
Wittig reagent for vinyl isocyanides synthesis
Isocyanomethyltriphenylphosphonium chloride is a Wittig reagent used for the Z-selective synthesis of vinyl isocyanides from aldehydes1,2. It enables regio- and stereoselective isocyanovinylation, producing key intermediates for heterocyclic synthesis. Air- and bench-stable, it is a scalable and efficient tool for isocyanide synthesis in medicinal chemistry and material science.
Synonyms: (isocyanomethyl)triphenylphosphonium chloride; isocyanomethyltriphenylphosphonium chloride; (isocyanomethyl)triphenylphosphanium chloride
Selected publications
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Synthesis of Vinyl Isocyanides and Development of a Convertible Isonitrile.
Spallarossa M.; Wang Q.; Riva R.; Zhu J. Org Lett 2016, 18 (7), 1622–1625. DOI: 10.1021/acs.orglett.6b00483
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Isocyanomethyltriphenylphosphonium Chloride.
Wang Q.; Zhu J. Encyclopedia of Reagents for Organic Synthesis 2019, 1–3. DOI: 10.1002/047084289X.rn02172