HOTT

CAS 212333-72-7, Cat. No EN300-7375554
Reagent for peptide synthesis, Barton esterification

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HOTT is a reagent used to convert carboxylic acids into Barton esters, facilitating reductive and oxidative decarboxylation, peptide coupling, and amidation¹. This white solid reagent should be protected from light due to the sensitivity of 2-mercaptopyridine N-oxide. HOTT is an efficient and easy-to-handle reagent that simplifies work-up processes in various organic synthesis applications. In the case of peptide synthesis, the reaction conditions are very mild and do not adversely affect other functionalities prone to nucleophilic attack. A simple extractive work-up is sufficient to obtain the primary amides in pure form.

Synonyms: S-(1-oxido-2-pyridinyl)-1,1,3,3-tetramethylthiouronium hexafluorophosphate; N,N,N',N'-tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate