EDC

CAS 25952-53-8, Cat. No EN300-21655
Reagent for the coupling of peptides, and synthesis of amides and esters

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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) is a versatile reagent extensively used for peptide coupling and the synthesis of amides and esters. Comparable to DCC and other carbodiimides, EDC exhibits similar reactivity. However, EDC offers a notable advantage over DCC: generated urea byproduct is water-soluble, enabling easy extraction and purification. It is a hygroscopic white powder displaying good solubility in most organic solvents. In combination with N-hydroxysuccinimide (NHS), EDC proves highly effective in conjugating smaller molecules, such as small peptides or fluorescent tags, to larger biomolecules in aqueous solutions. This approach allows the conjugation of various compounds, including proteins, DNA/RNA, and antibodies¹.

Synonyms: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; (3-{[(ethylimino)methylidene]amino}propyl)dimethylamine hydrochloride; 1,3-propanediamine, N′-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride (9CI); carbodiimide, [3-(dimethylamino)propyl]ethyl-, monohydrochloride (8CI); 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide monohydrochloride; 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride; 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride; 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide monohydrochloride; 3-[3-(dimethylamino)propyl]-1-ethylcarbodiimide hydrochloride; [3-(dimethylamino)propyl]ethylcarbodiimide hydrochloride; N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride; N-[(ethylimino)methylene]-N′,N′-dimethylpropane-1,3-diamine hydrochloride; N-[3-(dimethylamino)propyl]-N1-ethylcarbodiimide hydrochloride; N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride; N1-((ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride