DiCMA

CAS 477558-77-3, Cat. No EN300-39916247
Reagent for dichloroacetylation

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Dichloromeldrum’s acid (DiCMA) is a bench-stable reagent used for the dichloroacetylation of primary amines under mild, green conditions¹. It efficiently converts anilines, benzylamines, and alkylamines into α,α-dichloroacetamides at room temperature without the need for catalysts, bases, or preactivation. The reaction is clean, generating only acetone and CO₂ as byproducts. DiCMA offers a broad substrate scope and excellent atom economy, making it a sustainable alternative to dichloroacetyl chloride. The simplicity, scalability, and low environmental impact make DiCMA valuable for pharmaceutical and synthetic applications.

Synonyms: 5,5-dichloro-2,2-dimethyl-1,3-dioxane-4,6-dione; 5,5-dichloro-2,2-dimethyl[1,3]dioxane-4,6-dione; dichloromeldrum’s acid