Di-tert-butyl chloromethyl phosphate

CAS 229625-50-7, Cat. No EN300-316539
Reagent for phosphorylation and alkylation

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Di-tert-butyl chloromethyl phosphate is a phosphorylating and alkylating agent commonly used for alcohols and nitrogen-containing heterocycles modification to improve aqueous solubility¹. It enables the O- and N-alkylation of alcohols and heterocycles respectively, with applications spanning from medicinal chemistry to synthesizing complex organic molecules. The reagent is a colorless viscous liquid, soluble in water, toluene, dichloromethane, etc.

Synonyms: di-tert-Bu chloromethyl phosphate; phosphoric acid, chloromethyl bis(1,1-dimethylethyl) ester; chloromethyl di-tert-butyl phosphate; di t-Bu chloromethyl phosphate; phosphoric acid di(tert-butyl) chloromethyl ester; phosphoric acid di-tert-butyl ester chloromethyl ester