CAS 799797-29-8, Cat. No EN300-9136061
Reagent for sulfonylation of activated alkenes
4-(Trifluoromethyl)benzenesulfonohydrazide is a versatile and environmentally friendly reagent for synthesizing β-sulfone esters, and amides under mild and catalyst-free or metal-free conditions1. This reagent enables efficient sulfonylation of activated alkenes in water, yielding mono-substituted ethyl sulfones with broad substrate compatibility and high efficiency. Using hypervalent iodine reagents, it can also generate thiosulfonate and disulfide2. 4-(Trifluoromethyl)benzenesulfonohydrazide is stable, easy to handle, and compatible with aqueous and organic solvents, making them ideal for sustainable organic synthesis.
Synonyms: 4-(trifluoromethyl)benzene-1-sulfonohydrazide
Selected publications
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Catalyst-Free Sulfonylation of Activated Alkenes for Highly Efficient Synthesis of Mono-Substituted Ethyl Sulfones in Water.
Yang Y.; Tang L.; Zhang S.; Guo X.; Zha Z.; Wang Z. Green Chemistry 2014, 16 (9), 4106–4109. DOI: 10.1039/c4gc00932k
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Hypervalent Iodine Mediated Synthesis of Thiosulfonates from Sulfonyl Hydrazides and Their Transformation into Symmetrical Disulfides.
Yadav A.; Kumar R.; Prasad V. Synthesis 2024, 56 (12), 1923–1931. DOI: 10.1055/a-2260-0346