CAS 2958601-94-8, Cat. No EN300-27685907
SnAP reagent
2-((Tributylstannyl)methoxy)cyclopentanamine is used for the direct synthesis of piperazines and morpholines from aldehydes1. It enables a one-step transformation under mild conditions, making it valuable for medicinal chemistry. The reagent is compatible with aromatic, heteroaromatic, and aliphatic aldehydes, allowing the formation of diverse N-heterocycles. It is particularly useful for synthesizing bioactive molecules commonly found in pharmaceuticals. Air- and moisture-stable, it can be stored for weeks without decomposition.
Synonyms: 2-((tributylstannyl)methoxy)cyclopentanamine; 2-[(tributylstannyl)methoxy]cyclopentan-1-amine
Selected publications
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SnAP Reagents for the Synthesis of Piperazines and Morpholines.
Luescher M. U.; Vo C. V. T.; Bode J. W. Org Lett 2014, 16 (4), 1236–1239. DOI: 10.1021/ol500210z