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2-[(Fluoromethyl)sulfonyl]-pyridine

CAS 1365765-53-2, Cat. No EN300-7376553
Reagent for monofluoroalkylation

2-[(Fluoromethyl)sulfonyl]-pyridine
EN300-7376553

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2-[(Fluoromethyl)sulfonyl]-pyridine is a reagent used in monofluoroalkylating methodologies, enabling the selective introduction of fluorinated groups into aromatic and heteroaromatic compounds1. It serves as a precursor for the synthesis of derivatives such as 2-[(fluoroiodomethyl)sulfonyl]-pyridine, which plays a pivotal role in copper-mediated monofluoromethylation reactions2. Other important derivatives can be used in multiple transformations, including Julia-Kocienski olefination and depyridination, offering pathways to cyclomonofluoroalkenes and methylsulfones.

Synonyms: fluoromethyl 2-pyridyl sulfone; 2-((fluoromethyl)sulfonyl)pyridine

Selected publications

  1. Copper-Catalyzed Debenzoylative Monofluoromethylation of Aryl Iodides Assisted by the Removable (2-Pyridyl)Sulfonyl Group.

    Zhao Y.; Ni C.; Jiang F.; Gao B.; Shen X.; Hu J. ACS Catal 2013, 3 (4), 631–634. DOI: 10.1021/cs4000574

  2. 2-[(Fluoroiodomethyl)Sulfonyl]-Pyridine.

    Hu J.; Jiang F. Encyclopedia of Reagents for Organic Synthesis 2015, 1–3. DOI: 10.1002/047084289X.rn01756

 

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