Trivalent 1,3,5-Benzene Probe Platform

Creation of residue-selective biochemical probes and DNA-encoded chemical libraries often requires small and robust molecular platforms for attaching three functional groups with orthogonal reactivity. A trivalent sensor scaffold typically incorporates a selective electrophilic probe, such as sulfonyl fluoride (for Lys, Tyr), acrylamide (Cys), boronic acid (Ser, Thr), bromacetamide (Cys), aldehyde (Cys, Ser), alongside a chemical handle for click chemistry: alkyne, azide, and/or sulfonyl fluoride/fluorosulfate moieties. Discover Enamine’s collection of about 200 benzene-1,3,5-triyl (phentriyl) molecules bearing three orthogonally reactive groups!