1,1,1-Trifluoroisopropyl is a fluoroalkyl moiety that has made a significant impact on recent drug discovery. Two drugs featuring this fragment, Vorasidenib and Pirtobrutinib, have recently received FDA approval, and at least ten others have advanced to various stages of clinical trials. This innovative fluoroalkyl group enhances potency, improves CNS penetration, and reduces metabolic clearance. Explore our collection of 1,1,1-trifluoroisopropyl compounds and their closest analogues, 1,1-difluoroisopropyl substances.
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Over 100 1,1,1-trifluoroisopropyl and 1,1-difluoroisopropyl compounds from stock on 5-10 gram scale.
