Over the past two decades, spirocyclic moieties have found increasing application following the introduction of the "escape from flatland" strategy. These moieties enhance substance's metabolic stability and permeability. Incorporating an oxygen atom into the spirocyclic core produces structures with significantly lower lipophilicity and improved solubility, resulting in more favorable pharmaceutical properties. Explore Enamine’s collection of oxa-spirocycles, exemplified here by spirocyclic amines.
Concept
We offer
Over 100 oxa-spiroalkyl amines from stock on 5-10 gram scale.
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