Non-traditional fluoroalkyl groups
A wide variety of fluoroaliphatic moieties remain severely underexplored in drug design, in contrast to the CF3-group, which is among the most frequently found fragments in modern pharmaceuticals. In recent years, a growing set of examples have demonstrated a considerable potential of variable non-traditional fluoroalkyl groups in both, medicinal chemistry and agrochemical fields. These structures may address the issues associated with lipophilicity profile and metabolic degradation schemes of biologically active molecules.
More than 100 non-traditional fluoroaliphatic compounds from stock on a 5-10 g scale.