Nitrofuran has been traditionally used in antiseptic agents such as Furantoin and Nitrofurazone. A breakthrough study from 2018 identified the nitrofuran fragment as a cysteine-binding moiety for STING inhibitors, thus enhancing the arsenal of cysteine-binding warheads. The moiety acts as a compact warhead that enhances binding by orders of magnitude, forming thionitrozo derivatives, and delivers an optimal balance between potency and target selectivity. Explore Enamine’s collection of nitrofuran compounds for cysteine-targeting applications.
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Over 50 nitrofurans from stock on 5-10 gram scale.
