N-Hydroxyphthalimide (NHPI) Esters for Cross-coupling

In recent years, N-Hydroxyphtalimide (NHPI) esters have proven excellent synthetic precursors for mild and selective radical C-C cross-coupling reactions, enabling the incorporation of small aliphatic sp³-rich fragments into bioactive substances through photochemical, electrochemical, and organozinc processes. NHPI esters are highly selective, easy-to-handle solids that are compatible with bioorthogonal reactions and parallel chemistry settings. NHPI esters can be derived from virtually any carboxylic acid, suggesting significant potential for generating extensive libraries of molecules containing aliphatic fragments.