Bridging has demonstrated exceptional success in optimizing piperazine linkers across a range of drugs and lead molecules. These structural motifs effectively constrain molecular conformation variability, achieving this with only a minimal increase in molecular volume and weight. Interestingly, recent studies reveal that bridging can, somewhat counterintuitively, reduce a compound’s lipophilicity even as molecular weight increases. Try Enamine’s collection of bridged piperazine molecular scaffolds!
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Over 100 bridged piperazines from stock on 5-10 gram scale.
