The aziridine ring serves as a key warhead moiety in FDA-approved drugs mitomycin and thiotepa, as well as in several recent investigational compounds. Under specific cellular conditions, this ring system opens, enabling DNA cross-linking and the inactivation of endogenous enzymes in cancer cells and pathogenic bacteria. In organic synthesis, the use of aziridines has expanded significantly in recent years, particularly with the use of N-tosyl aziridine reagents. Explore our collection of over 50 aziridines suitable for both synthesis applications and warhead design.
Reactions
We offer
Over 50 aziridines from stock on 5-10 gram scale.
