Amino acid surrogates are less recognizable to endogenous peptidases, thereby they effectively reduce metabolic clearance, extending the duration of action for peptide and peptide-derived pharmaceuticals. Azetidino acids represent a class of promising amino acid surrogates, as they maintain similar structural distances to natural amino acids and lack issues with reactivity and chirality. Unlike α-amino acids, where α-fluoro, hydroxy, or amino substitutions are unstable, azetidino acids form stable structures, enabling substitution patterns that are unattainable in natural amino acids and peptides.
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Over 100 azetidine-3-carboxylic acids from stock on 5-10 gram scale.
