To date, over 700 FDA-approved drug structures have been based on the simple and reliable geometry of the benzene ring. However, this geometry only provides discrete parameters, such as 180° and 120° exit angles for para- and meta-phenylene scaffolds, respectively. Meanwhile, several promising saturated skeletons produce angles of approximately 150°, serving as hybrid surrogates that enable exploration of the otherwise inaccessible intermediate angle between para- and meta-substitution. The bicyclic skeletons maintain a molecular volume similar to that of the benzene ring, while high three-dimensionality helps reduce susceptibility to metabolic clearance. Inclusion of oxygen atoms reduces lipophilicity and markedly improves solubility of the structures.
Concept
We offer
Over 250 para-/meta- aliphatic surrogates from stock on 5-10 gram scale.
