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  • A New Synthetic Route Reported For 1-(Trimethylsilyl)vinyl MIDA boronate, A Suitable Trifunctional Building Block

A New Synthetic Route Reported For 1-(Trimethylsilyl)vinyl MIDA boronate, A Suitable Trifunctional Building Block

Recent publicationby our chemists describes gram-scale synthesis and some chemical transformations of novel trifunctional C 2building blocks – MIDA boronate shown below. This small molecule can be selectively modified by any of the three functional groups ( i.e.alkene, boronate and TMS). Such building blocks were highlighted by Burke’s group in their Nature paperreporting iterative chemoselective cross-coupling to form polyene natural products, similar to the use of N-Fmoc amino acids for the synthesis of peptides.

We have prepared a set of MIDA boronatesfor your research. You can also find many other functionalized boronic acid derivatives at EnamineStore.

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