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Enamine Launched Peptide Synthesis Laboratory

Solid-Phase Peptide Synthesis was launched by Enamine with a new PS3 Peptide synthesizer (Protein Technologies, Inc.). Small linear and cyclic peptides comprising 2 to 25 amino acid residues of both natural and unnatural origin can be prepared on 1-30 mg scale in a highly pure form (>95%). A large collection of proprietary unnatural amino acids including many conformationally constrained ones as well as ones containing fluorine substituents can be used to expand the variety of peptides. The example structures of peptides prepared with our new peptide synthesizer are listed below.

CF3-Labeled Gramicidin-S analogue Cell-penetrating peptide SAP-E
CF3-Labeled Gramicidin-S analogue
( Angew.Chem., Int. Ed. Engl . 2006 , 45 , 5659-5661)
Cell-penetrating peptide SAP-E
( ChemBioChem 2011, 12 , 896-903)
  CF3-Labeled SAP analogue
CF3-Labeled SAP analogue ( Angew. Chem. Int. Ed. 2008 , 47 , 5765 –5767 )

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