4th Drug Discovery Nexus Summit - Enamine

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Building Blocks
Functional classes

DEL-compatible scaffolds
Azides / Click Chemistry
Carboxylic acids
Aldehydes
Alkyl Halides
Aryl Halides
Boronic Acid Derivatives
Primary Amines
Secondary Amines
Sulfonyl Chlorides/Fluorides
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MedChem Highlights

Aliphatic Trifluoroborates (-BF₃) for C-C couplings
Functionalized Vinyl Boronates for C-C couplings
Unique 3D-shaped Spirocycles to Explore Novel Chemical Space
Water-soluble non-classical benzene mimics
gem-Difluorinated Amines for Drug Design
Fluorosulfates and Sulfamoyl Fluorides for Drug Design
Alkyne-containing Linkers
Structurally optimized tetrazines for rapid biological labeling
Building blocks and linkers for PROTAC synthesis
Heterocyclic Sulfonyl Fluorides
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Synthesis of New Building Blocks

Make-on-Demand Building Blocks
Custom Synthesis
Chiral separation
Library Synthesis
REAL Compounds

REAL Database
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Scaffold Decoration
Compound Collection Enhancement
FTE Chemistry Support
Hit Finding
Diversity Libraries

10 560 compounds
50 240 compounds
Hit Locator Library
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Covalent Screening Library
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Antiviral Library
GPCR Library
PPI Library
CNS Library
Coronavirus Library
RNA Library
Glycomimetic Library
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Compound collections

Screening Collection
REAL Database
Fragments
Covalent Compounds
Macrocycles
BioReference Compounds
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High-Throughput Screening
In silico modeling
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REAL Space
Fragments
Plated Libraries

DSI-poised Library
Essential Fragment Library
High Fidelity Fragment Library
Covalent Fragment Library
Natural Product-like Fragments
3D Shape Diverse Library
PPI Fragment Library
Covalent Fragments

Warhead Subsets
CYS focused Library
SER focused Library
LYS focused Library
Acrylamides
Fragment Collection

MiniFrag Library
sp³ Rich Fragments
Single Pharmacophore
Carboxylic Acid Fragments
Fluorinated Fragments
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Analogues search
Turbidity assay
Fragments pooling
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Chemistry services

Library synthesis
Custom synthesis
FTE Chemistry Support
Biology services

High-Throughput Screening
In vitro ADME
In vivo PK/Tox
Functional Compounds

CeMM Library of Unique Drugs (CLOUD)
BioReference Compounds
Impurity Reference Standards

Building Blocks
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MedChem Highlights
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4th Drug Discovery Nexus Summit

May 16 - 17

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Boston, MA, USA

4th Drug Discovery Nexus Summit

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