The world’s largest collection of Acrylamides
34 911 in stock and over 31.5M in REAL Database
Covalent modifiers have re-emerged as a drug design strategy due to more and more examples of their successful applications and safety. Acrylamides are the most frequently used covalent warheads with proven moderate reactivity and high selectivity to cysteine residue. Our efforts in synthesis of new covalent binders with acrylamide warhead yielded a collection of over 34 900 compounds – the largest source of commercially available acrylamides.
Typical Formats
Catalog No.
sACR-4160-10-Y-10
Compounds
4 160
13 plates
Amount
10 µL of 10 mM DMSO solutions
Plates and formats
384-well plates Greiner 781280, 320 compounds per plate, first two and last two columns empty
Price
Catalog No.
fACR-2240-25-Y-100
Compounds
2 240
7 plates
Amount
25 µL of 100 mM DMSO solutions
Plates and formats
384-well plates Greiner 781280, 320 compounds per plate, first two and last two columns empty
Price
Catalog No.
sACR-4160-50-X-10
Compounds
4 160
52 plates
Amount
50 µL of 10 mM DMSO solutions
Plates and formats
96-well plates, Greiner Cat. No 650201, round (U) bottom, 80 compounds per plate, 1 & 12 columns empty
Price
Download SD files
34 911 compounds for cherry-picking
Plated libraries in stock:
Key features
- Unprecedented Novelty of our acrylamides supported by continuous enrichment with the latest Enamine’s building blocks and unique amines. Over 2 000 new acrylamides are synthesized each year.
- High Diversity of core structures ensured by careful selection of diverse intermediates possessing variety of chemotypes.
- Ready-to-use non-overlapping pre-plated sets can be promptly supplied in customized format only within 1-2 weeks:
Representative examples of well-known actives bearing acrylamide moiety and similar structures from Enamine’s in-stock Acrylamides:
All compounds are 90%+ pure (LCMS and/or NMR analysis) and can be delivered as dry powders or in any customized plated formats. Identified hits can be readily re-synthesized and followed with analogs in stock or fast parallel synthesis within only 3 weeks.
You can acquire new compounds from our pool of 31.5M REAL acrylamides. Synthesis takes only 3-4 weeks yielding over 80% of the selected compounds.
Link on the SD file with almost 31.5M of new Acrylamides accessible within only 3-4 weeks.
The world-largest and most diverse
50 272 compounds
Since 2000s, when the “Escape from Flatland” concept implying increase of saturation degree (Fsp3) and presence of chiral centers was introduced, numerous medicinal chemistry projects involving design and screening of sp3-enriched structures have appeared.
sp3 rich Fragments have been selected from Enamine Screening & Building Blocks Collections by applying strict Ro3 criteria, with Fsp3 cutoff at 0.47, and standard industry affiliated filters including PAINS. The final set of compounds has been evaluated to exclude simple reagents and trivial chemotypes resulting in a library of over 50 272 small molecules available for cherry-picking. Since the fragments with aromatic moieties are believed to demonstrate improved hit rate in screening, the set was enriched with compounds having the optimal Fsp3 values (0.47–0.75).
Novelty, high chemical and structural diversity of Enamine's sp3 rich fragments will make more efficient any search of new ligands for challenging targets.
Examples of the molecules
61 378 compounds
Enamine Premium Collection contains 61 378 compounds having most favorable physicochemical properties (high Fsp3, low LogP and MW). They have been synthesized in our lead-oriented synthesis program. Remarkable success achieved by Enamine in synthesizing novel lead-like compound libraries is explained by usage of robust and sustainable chemical methodology which concept is based on development of the building block inventory. While designing new molecular scaffolds we not only address the issue of physicochemical properties and pharmacophore composition of the derived compounds but also the cost factor related to follow-up of the found hits. Owing to the high degree of chemistry validation and availability of the analogous building blocks from our catalog the hit-to-lead process runs fast and smoothly.
Examples of compounds from Premium collection
1 771 342 compounds
Enamine HTS Collection contains 1 771 342 diverse screening compounds. The collection encompasses versatile chemotypes developed within a couple of decades of chemical research at Enamine and its partner academic organizations. These compounds frequently have unusual structures and unique properties. The collection is particularly recommended for the researchers looking for most diverse screening set.
Examples of compounds from HTS collection
Z838844620
MW 399.2
cLogP 0.53
Z56866051
MW 378.3
cLogP 4.84
Z55436465
MW 449.5
cLogP -1.87
854 582 compounds
Enamine Advanced Collection contains 854 582 compounds that have lead-like properties with MW ≤ 350, cLogP ≤ 3, and rotB ≤ 7 and/or valuable pharmacophores such carboxylic, primary amino and amide groups. This part of Enamine’s screening collection has been recognized as an important source of compounds for targeted library design. Multiple functional groups and lead-like properties of the compounds make sets selected from Advanced collection an ultimate tool for lead discovery. All compounds are checked with our in-house medchem filters.
Examples of compounds from Advanced collection
Z1002252374
MW 339.4
cLogP 1.89
Z1003149082
MW 340.4
cLogP 1.89
