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Recent News
11 April 2024
Press Release
Cambridge, UK and Kyiv, Ukraine, 11 April 2024: Metrion Biosciences Limited (“Metrion”), the specialist ion channel and cardiac safety screening contract research organisation (CRO) and drug discovery company, and Enamine Ltd (“Enamine”), the global leader in supplying small molecules and early drug discovery services, announced that Metrion has enhanced its High Throughput Screening (HTS) services with the addition of access to Enamine’s compound libraries.
27 March 2024
Press Release
March, 2024, Kyiv, Ukraine. Enamine Ltd, the global leader in supplying small molecules and early drug discovery services, announces the expansion of its library synthesis capabilities with a focus on Enamine REAL compounds to further support the growing demands of agricultural and pharmaceutical companies, research institutes, and drug discovery centers.
01 March 2024
News
We are excited to announce a strategic collaboration between Enamine, the world's leading provider of chemical building blocks, compound libraries, and biology services, and Genez International, a prominent enterprise with 15 years of experience in cross-border supply management, biopharmaceutical research and development, semiconductor equipment, and high-definition digital imaging systems.
Tetrahedron
2016, 72 (10), 1351-1356
DOI: 10.1016/j.tet.2016.01.032
Michurin O. M.; Radchenko D. S.; Komarov I. V.
Easily available difluoromethylating reagent Me3SiCF2H enables multigram synthesis of difluoromethyl alcohols in good yields under mild conditions from a number of aldehydes and ketones in the presence of HMPA. This additive makes possible the previously challenging nucleophilic difluoromethylation of enolizable ketones. DMPU can be used as a non-toxic alternative to the HMPA in the difluoromethylation reaction, albeit the yields were slightly lower in this case. The method works well with cyclic, acyclic, aryl ketones and tolerates various functional groups.