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Synthesis of isomeric (3,3,3-trifluoropropyl)anilines

J. Fluorine Chem. 2015, 171 174-176

DOI: 10.1016/j.jfluchem.2014.06.003

Trofymchuk S.; Bezdudny A.; Pustovit Y.; Mykhailiuk P. K.

Ortho-, meta- and para-isomers of (3,3,3-trifluoropropyl)aniline have been prepared in 60–70 g amount from the corresponding nitrobenzaldehydes in three steps. The key synthesis step was a transformation of the carboxylic group of 3-(nitrophenyl)propanoic acids into the trifluoromethyl group by SF4.

Synthesis of isomeric (3,3,3-trifluoropropyl)anilines

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