Synthesis of isomeric (3,3,3-trifluoropropyl)anilines
J. Fluorine Chem. 2015, 171 174-176
Ortho-, meta- and para-isomers of (3,3,3-trifluoropropyl)aniline have been prepared in 60–70 g amount from the corresponding nitrobenzaldehydes in three steps. The key synthesis step was a transformation of the carboxylic group of 3-(nitrophenyl)propanoic acids into the trifluoromethyl group by SF4.