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A Facile Synthesis of Isomeric C-(2,2,2-Trifluoroethyl)anilines

Synthesis , 2012, 44 (13), 1974-1976

DOI: 10.1055/s-0031-1290295

Trofymchuk S.; Bezdudny A. V.; Pustovit Y. M.; Lukin O.; Boyko A. N.; Chekotylo A.; Tolmachev A. A.; Mykhailiuk P. K.

Three isomers of C-(2,2,2-trifluoroethyl)aniline were prepared on a multigram scale from readily available nitrophenylacetic acids in two steps. First, the carboxy groups of the latter were converted into the trifluoromethyl moieties by treatment with sulfur tetrafluoride. The obtained 2,2,2-trifluoroethyl-substituted nitrobenzenes were reduced catalytically into the corresponding anilines.

A Facile Synthesis of Isomeric C-(2,2,2-Trifluoroethyl)anilines

Trofymchuk S.; Bezdudny A. V.; Pustovit Y. M.; Lukin O.; Boyko A. N.; Chekotylo A.; Tolmachev A. A.; Mykhailiuk P. K.
Synthesis 2012, 44 (13), 1974-1976
DOI: 10.1055/s-0031-1290295

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