More

  • Home
  • Research
  • Publications
  • Recyclization of 2-(3,6-diaryl-2,5-dihydropyridazin-4-yl)-1H-benzimidazoles to 2-[(3,5-diarylpyrazol-4-yl)methyl]-1H-benzimidazoles

Aminoheterocycles as synthons for combinatorial Biginelli reactions

Mol. Diver. , 2011, 15 (1), 189-195

DOI: 10.1007/s11030-010-9253-6

Ryabukhin S.; Plaskon A.; Boron S.; Volochnyuk D.; Tolmachev A.

Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the synthesis of diverse dihydropyrimidines via Biginelli type MCR-heterocyclization using aminoheterocycles. High yields and a simple workup of target compounds enable the facile generation of combinatorial libraries comprising more than 2 000 compounds of high structural and functional diversity. A representative set of 89 compounds is described.

Aminoheterocycles as synthons for combinatorial Biginelli reactions

Ryabukhin S.; Plaskon A.; Boron S.; Volochnyuk D.; Tolmachev A.
Mol. Diver. 2011, 15 (1), 189-195
DOI: 10.1007/s11030-010-9253-6

FOLLOW US

Contact us

Send a message