Building Blocks Catalog

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Building Blocks

1B novel building blocks

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2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from February 2024

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    Enamine Announces Expansion of Its Library Synthesis Capabilities

    March, 2024, Kyiv, Ukraine. Enamine Ltd, the global leader in supplying small molecules and early drug discovery services, announces the expansion of its library synthesis capabilities with a focus on Enamine REAL compounds to further support the growing demands of agricultural and pharmaceutical companies, research institutes, and drug discovery centers.

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    We are excited to announce a strategic collaboration between Enamine, the world's leading provider of chemical building blocks, compound libraries, and biology services, and Genez International, a prominent enterprise with 15 years of experience in cross-border supply management, biopharmaceutical research and development, semiconductor equipment, and high-definition digital imaging systems.

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    Cresset recently announced a collaboration with Enamine, the world’s leading provider of chemical building blocks and drug discovery services to develop innovative new solutions for the early drug discovery process.

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Collect. Czech. Chem. Commun. , 2009, 74 (2), 335-346

DOI: 10.1135/cccc2008095

Tarasenko K. V.; Gerus I. I.; Kukhar V. P.; Polovinko V. V.

New bromodifluoromethyl enaminones 1a-1f and γ-bromo-β- morpholinopropenyl fluoro-methyl ketones 2a, 2b were synthesized. N-Substituted bromodifluoromethyl enaminones 1a-1d do not react with triethyl or diethyl phosphites, whereas N-acylated enaminones 1e, 1f gave difluorodienyl phosphates 4a, 4b as Perkow rearrangement products. Fluoroketone 2a reacts easily with triethyl phosphite according to the Arbuzov protocol and a perspective building block - trifluoromethyl-containing phosphonate 7a is formed.

Reactions of β-aminovinyl bromodifluoromethyl ketones with alkyl phosphites: Perkow versus Arbuzov

Tarasenko K. V.; Gerus I. I.; Kukhar V. P.; Polovinko V. V.
Collect. Czech. Chem. Commun. 2009, 74 (2), 335-346
DOI: 10.1135/cccc2008095

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