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N-Substituted Ureas and Thioureas in Biginelli Reaction Promoted by Chlorotrimethylsilane: Convenient Synthesis of N1-Alkyl-, N1-Aryl-, and N1,N3-Dialkyl-3,4-Dihydropyrimidin-2(1H)-(thi)ones

Synthesis , 2007, 03, 417-427

DOI: 10.1055/s-2007-965881

Ryabukhin S. V.; Plaskon A. S.; Ostapchuk E. N.; Volochnyuk D. M.; Tolmachev A. A.

The classical Biginelli reaction has been extended by the use of N-substituted ureas and thioureas. A set of N1-alkyl-, N1-aryl-, and N1,N3-dialkyl-3,4-dihydropyrimidin-2(1H)-(thi)ones was readily prepared in excellent yield when chlorotrimethylsilane in N,N-dimethylformamide was used as promoter and water scavenger.

N-Substituted Ureas and Thioureas in Biginelli Reaction Promoted by Chlorotrimethylsilane: Convenient Synthesis of N1-Alkyl-, N1-Aryl-, and N1,N3-Dialkyl-3,4-Dihydropyrimidin-2(1H)-(thi)ones

Ryabukhin S. V.; Plaskon A. S.; Ostapchuk E. N.; Volochnyuk D. M.; Tolmachev A. A.
Synthesis 2007, 03, 417-427
DOI: 10.1055/s-2007-965881

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