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27 March 2024
Press Release
March, 2024, Kyiv, Ukraine. Enamine Ltd, the global leader in supplying small molecules and early drug discovery services, announces the expansion of its library synthesis capabilities with a focus on Enamine REAL compounds to further support the growing demands of agricultural and pharmaceutical companies, research institutes, and drug discovery centers.
01 March 2024
News
We are excited to announce a strategic collaboration between Enamine, the world's leading provider of chemical building blocks, compound libraries, and biology services, and Genez International, a prominent enterprise with 15 years of experience in cross-border supply management, biopharmaceutical research and development, semiconductor equipment, and high-definition digital imaging systems.
21 February 2024
Press Release
Cresset recently announced a collaboration with Enamine, the world’s leading provider of chemical building blocks and drug discovery services to develop innovative new solutions for the early drug discovery process.
Chem. Heterocycl. Compd.
2020, 56 (3), 377–385
DOI:
10.1007/s10593-020-02670-z
Stepaniuk O.; Vashchenko B.; Matvienko V.; Kondratov I.; Tolmachev A.; Grygorenko O.
Reactions of five- and six-membered cyclic β-alkoxyvinyl α-keto esters and NCC-binucleophiles are described. The following binucleophiles were studied: heteroaromatic amines (pyrazoles, isoxazole, uracils, and isoquinolinone) and 2-(benzimidazolyl)acetonitrile. It was found that condensation proceeded regioselectively in the case of five-membered cyclic enone. Fused α-pyridine carboxylates, likely formed in situ, underwent lactonization, which resulted in six-membered lactones in moderate to excellent yields (53–91%). Only in the case of 3-unsubstituted 5-aminopyrazole, formation of γ-pyridine carboxylate followed by cyclization to isomeric lactone was observed. On the contrary, six-membered cyclic enone was reactive only toward heterocyclic amines under optimized conditions and provided open-chain α-pyridine carboxylates in 40–80% yield.