These compounds are hydrolytically stable and can serve as convenient substitutes for analogues hardly available and unstable under normal laboratory conditions aliphatic sulfonyl chlorides. (Krutak J. J. et al.; J. Org. Chem.; 44; 1979; 3847 - 3858).
Fluoronyl sufonyl group is stable in the presence of aqueous acids and stable to most reaction conditions. Nevertheless, they could be converted by simple, one-step procedures to sulfamides.
These compounds allow effective introduction of sulfamide pharmacophore fragment in the molecules of screening compounds:
The screening compounds bearing aliphatic fragment tethered via a sulfamide linker to heterocycles are not widely spread on the market. Thus, these compounds are starting materials for novel and previously unexplored sulfamides. Screening Collection of Enamine also contains a number of various sulfamides prepared from the aliphatic sulfonyl fluorides and different amines and anilines.