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Cambridge, UK and Kyiv, Ukraine, 11 April 2024: Metrion Biosciences Limited (“Metrion”), the specialist ion channel and cardiac safety screening contract research organisation (CRO) and drug discovery company, and Enamine Ltd (“Enamine”), the global leader in supplying small molecules and early drug discovery services, announced that Metrion has enhanced its High Throughput Screening (HTS) services with the addition of access to Enamine’s compound libraries.
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March, 2024, Kyiv, Ukraine. Enamine Ltd, the global leader in supplying small molecules and early drug discovery services, announces the expansion of its library synthesis capabilities with a focus on Enamine REAL compounds to further support the growing demands of agricultural and pharmaceutical companies, research institutes, and drug discovery centers.
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We are excited to announce a strategic collaboration between Enamine, the world's leading provider of chemical building blocks, compound libraries, and biology services, and Genez International, a prominent enterprise with 15 years of experience in cross-border supply management, biopharmaceutical research and development, semiconductor equipment, and high-definition digital imaging systems.
Russ. J. Coord. Chem.
2017, 43 (10), 619–629
DOI:
10.1134/s1070328417100086
Polunin R. A.; Kiskin M. A.; Gavrilenko K. S.; Imshennik V. K.; Maksimov Y. V.; Eremenko I. L.; Kolotilov S. V.
Coordination polymers [Fe2MO(Piv)6(L1) x ] n · nSolv (L1 = 1,2-bis(4-pyridyl)ethane, M = Ni (I), Co (II), x = 1.5; M = Cо (III), x = 2) are synthesized. Depending on the synthesis conditions, compounds II (cross diffusion of reactants) or III (fast mixing of reactant solutions) of different compositions are formed. It is shown by X-ray diffraction analysis (CIF files CCDC 1550804 (I) and 1550805 (III)) that compound I is a porous coordination polymer built of parallel 2D layers and compound III is a 1D coordination polymer. The crystals of complexes I and II are isostructural. The mutual arrangement of the 2D layers in compound II depends on the solvent in which this coordination polymer is formed. The desolvation of polymers I and II leads to the collapse of the crystal lattice. Unlike the complexes with L1, [Fe2NiO(Piv)6(L2)1.5] n · nSolv (IV · nSolv) is formed in the case of 4,4'-bipyridine (L2), regardless of the solvent nature, and its crystal lattice is formed by interpenetrating 2D layers. The mutual arrangement of the 2D layers in the crystal lattice of compound IV varies with the solvent used for the synthesis of this coordination polymer or for the resolvation of a sample of polymer IV. It is found that the parameters of the 57Fe Mössbauer spectra for compounds IV and IV · nDEF (DEF is N,N-diethylformamide) differ, which can be explained by a decrease in the symmetry of the coordination environment of the Fe3+ ions when the pores are filled with DEF molecules.
![Influence of the Synthesis Conditions and the Presence of Guest Molecules on the Structures of Coordination Polymers [Fe<sub>2</sub>MO(Piv)<sub>6</sub>(L) <sub>x</sub> ] <sub>n</sub> (L = 4,4′-Bipyridine, Bis(4-Pyridyl)ethane) with the Labile Crystal Lat](/images/publications/Influence-of-the-Synthesis.PNG)
