A Facile Synthesis of Isomeric C-(2,2,2-Trifluoroethyl)anilines
Synthesis , 2012, 44 (13), 1974-1976
Three isomers of C-(2,2,2-trifluoroethyl)aniline were prepared on a multigram scale from readily available nitrophenylacetic acids in two steps. First, the carboxy groups of the latter were converted into the trifluoromethyl moieties by treatment with sulfur tetrafluoride. The obtained 2,2,2-trifluoroethyl-substituted nitrobenzenes were reduced catalytically into the corresponding anilines.
Trofymchuk S.; Bezdudny A. V.; Pustovit Y. M.; Lukin O.; Boyko A. N.; Chekotylo A.; Tolmachev A. A.; Mykhailiuk P. K.
Synthesis 2012, 44 (13), 1974-1976