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11 April 2024
Press Release
Cambridge, UK and Kyiv, Ukraine, 11 April 2024: Metrion Biosciences Limited (“Metrion”), the specialist ion channel and cardiac safety screening contract research organisation (CRO) and drug discovery company, and Enamine Ltd (“Enamine”), the global leader in supplying small molecules and early drug discovery services, announced that Metrion has enhanced its High Throughput Screening (HTS) services with the addition of access to Enamine’s compound libraries.
27 March 2024
Press Release
March, 2024, Kyiv, Ukraine. Enamine Ltd, the global leader in supplying small molecules and early drug discovery services, announces the expansion of its library synthesis capabilities with a focus on Enamine REAL compounds to further support the growing demands of agricultural and pharmaceutical companies, research institutes, and drug discovery centers.
01 March 2024
News
We are excited to announce a strategic collaboration between Enamine, the world's leading provider of chemical building blocks, compound libraries, and biology services, and Genez International, a prominent enterprise with 15 years of experience in cross-border supply management, biopharmaceutical research and development, semiconductor equipment, and high-definition digital imaging systems.
ChemistrySelect
2019, 4 (17), 4933-4937
DOI:
10.1002/slct.201900650
Omelian T.; Dobrydnev A.; Ostapchuk E.; Volovenko Y. M.
We report a strategy for the construction of tetrahydro‐1H‐1λ6‐pyrrolo[1,2‐b]isothiazole‐1,1,3(2H)‐triones bearing the substituents at the 5‐ and/or 3a‐positions. To this purpose, a range of 2‐substituted and 2,4‐disubstituted methyl 2‐pyrrolidinecarboxylates were sulfonylated with methanesulfonyl chloride and the resulting sulfonamides were subjected to sulfa‐Dieckmann condensation through the CSIC (Carbanion mediated Sulfonate (Sulfonamido) Intramolecular Cyclization) reaction to give the desired 1λ6‐isothiazolidine‐1,1,4‐triones. All the precursors, as well as target compounds, could be synthesized in a multigram scale following the general protocols.