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Protein Degrader Toolbox

Ready-to-use tools for your discovery

One of the most emerging therapeutics area focused on modulation of ubiquitin proteasome system (proteolysis targeting chimeras, PROTACs) is very much in need of new and robust chemistry. Booming biological assays in this field of drug development require production of dozens and hundreds of new bifunctional molecules. The time needed for production of new derivatives is crucial for any new project in this therapeutic area.

To facilitate all further work on bifunctional linked molecules we have developed a stand-alone toolbox. This customized compound set was created from only in-stock intermediates and verified in-house chemistry to facilitate further production of new conjugates.

Cereblon ligands and ligands with linkers
VHL ligands and ligands with linkers
Orthogonal Linkers
Molecular Glues
Functionalized Warhead Ligands
Active Degraders

We offer distinct tools that you can mix-up to design molecules of your special interest. The following options are available for synthesis of new molecules or immediate delivery to your research site:

  • Ubiquitin ligases recognition ligands
  • Orthogonal PEG-linkers and their carba-analogs
  • Functionalized Warhead Ligands
  • Active degraders
  • Molecular Glues

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