CRBN binders and their functionalized analogs
Cereblon (CRBN) is one of the most explored E3 ligases extensively used to construct PROTACs, search for new Molecular Glues, and develop functionalized tool compounds. The most extensive research has been done in this area. CRBN ligands are also known to have a good ADME profile, allowing for the development of orally bioavailable PROTACs.
We have been working with Thalidomide-like and Glutarimide chemistry for years and gained versatile experience in this chemistry field. Our experienced chemists are continuously working on the design and synthesis of new attractive Building Blocks, while our parallel chemistry group extensively elaborates approaches in the modification of the most interesting intermediates. This knowledge allowed us to enumerate a REAL Array of over 18 million CRBN-focused compounds, which can be synthesized within only 4 weeks and with 80% success rate.
Screening Compounds and Libraries
Over 15 000 CRBN focused compounds are available from stock including Glutarimides, IMiD Library Uracil-like, and Avadomide derivatives. All products are constantly updated with newly synthesized compounds. Covalent modifiers are represented by diverse and the most reliable warheads focusing on Cys, Lys, and Ser residues.
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Plated
Stock
REAL
Product catalog
IMiD Library
IMiD-4900
Size
4 900
compounds
Descriptions
Designed and specially synthesized for the discovery of Immunomodulatory Imide Drugs
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CRBN Molecular Glues Library
CRBN-MG-4560
Size
4 560
compounds
Description
Designed to capture the widest possible range of novel chemotypes of CRBN binders, providing a foundation for the discovery of next-generation Molecular Glues
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PAG Library
PAG-640
Size
640
compounds
Description
Built upon novel Phenyl Amino Glutarimide (PAG) analogs, these compounds combine structural innovation with potent activity — offering a fresh perspective in Molecular Glue design
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PD Library
PD-880
Size
880
compounds
Description
Chemical stability, cellular potency, and permeability are just a few of the advantages that make Phenyl Dihydrouracil (PD)-based CRBN ligands promising candidates for optimal Molecular Glue discovery
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PG Library
PG-800
Size
800
compounds
Description
Phenyl Glutarimide (PG)-based library was purposefully developed to expand the structural diversity space of Molecular Glues
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Len Library
Len-640
Size
640
compounds
Description
Lenalidomide- and Pomalidomide-scaffold based — a time-tested backbone, reimagined for modern Molecular Glue design
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AAG Library
AAG-1600
Size
1 600
compounds
Description
Acylated Amino Glutarimide (AAG) featuring 5- and 6-membered heterocyclic systems: a promising platform for the discovery of next-generation Molecular Glues
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Avadomide library
AVD-560
Size
560
compounds
Descriptions
A special selection of new Avadomide analogs
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Diverse CRBN Library
CRBN-960
Size
960
compounds
Descriptions
Designed to cover all structural diversity of CRBN binders, a key component of the E3 ubiquitin ligase complex
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CRBN Covalent Library
CCRBN-160
Size
160
compounds
Descriptions
A small selection of diverse covalent binders capable of interacting with CRBN
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Representative examples of compounds in pre-plated CRBN Diversity Library
Examples of compounds in pre-plated CRBN Covalent Library
Examples of in-stock CRBN binders with linkers
Latest Arrivals
Glutarimide ring variation
Imide motif variation
Core structure variation
