Cereblon ligands and functionalized intermediates
CRBN binders and their functionalized analogs
Cereblon (CRBN) is one of the most explored E3 ligases extensively used to construct PROTACs, search for new Molecular Glues, and develop functionalized tool compounds. The most extensive research has been done in this area. CRBN ligands are also known to have a good ADME profile, allowing for the development of orally bioavailable PROTACs.
We have been working with Thalidomide-like and Glutarimide chemistry for years and gained versatile experience in this chemistry field. Our experienced chemists are continuously working on the design and synthesis of new attractive Building Blocks, while our parallel chemistry group extensively elaborates approaches in the modification of the most interesting intermediates. This knowledge allowed us to enumerate a REAL Array of over 8 million CRBN-focused compounds, which can be synthesized within only 4 weeks and with 80% success rate.
Screening Compounds and Libraries
Over 11 000 CRBN focused compounds are available from stock including Glutarimides, IMiD Library Uracil-like, and Avadomide derivatives. All products are constantly updated with newly synthesized compounds. Covalent modifiers are represented by diverse and the most reliable warheads focusing on Cys, Lys, and Ser residues.
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11 452 compounds
Library code: CRBN-960
Version: 14 March 2024
960 compounds
at 20 mM in DMSO
sublibrary of IMiD-4900
2 669 compounds
560 compounds
528 compounds
180 compounds
405 compounds
Typical Formats
Catalog No.
IMiD Library
IMID-4900-10-Y-20
Compounds
4 900
16 plates
Amount
10 µL of 20 mM DMSO solutions
Plates and formats
384-well Echo Qualified plates, 320 compounds per plate, first two and last two columns empty
Price
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Catalog No.
Diverse CRBN Library
CRBN-960-25-Y-20
Compounds
960
3 plates
Amount
25 µL of 20 mM DMSO solutions
Plates and formats
384-well Greiner plates, 320 compounds per plate, first two and last two columns empty
Price
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Catalog No.
Covalent CRBN Library
CCRBN-160-50-X-20
Compounds
160
2 plates
Amount
50 µL of 20 mM DMSO solutions
Plates and formats
96-well Greiner plates, 80 compounds per plate, first and last columns empty
Price
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Catalog No.
CRBN Library
CRBN-960
Compounds
960
Amount
Custom
Plates and formats
Any custom format
Price
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All our screening compounds can be represented by the following subclasses and types of CRBN binders:
- All Glutarimides in stock – 5 758 compounds
- Lenalidomide scaffold-based molecules – 2 720 compounds
- Thalidomide-like derivatives with linkers – 300 compounds
- REAL Molecular Glues – 4M+ compounds
- CRBN ligands with linkers – 300 compounds
- REAL CRBN ligands with covalent warheads
We are constantly working on the update and synthesis of new derivatives of known binders and new potential CRBN ligands.
Representative examples of compounds in pre-plated CRBN Diversity Library
Examples of compounds in pre-plated CRBN Covalent Library
Examples of in-stock CRBN binders with linkers
Building Blocks
- CRBN 1st generation Intermediates – 600 compounds
- CRBN 2nd generation Intermediates – 200 compounds
- CRBN 3rd generation 5-membered Intermediates – 400 compounds
- CRBN MADE Building Blocks – over 80 000 intermediates.
Latest Arrivals
Glutarimide ring variation
Imide motif variation
