3-(Trifluoromethyl)benzenesulfonyl hydrazone

CAS 890522-54-0, Cat. No EN300-9131645
Reagent for ketones synthesis

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3-(Trifluoromethyl)benzenesulfonyl hydrazone is a base-promoted reagent for the synthesis of ketones from aldehydes without metal catalysts¹. It enables a safer alternative to diazo chemistry, avoiding explosive intermediates. The reaction proceeds via a cyclic intermediate pathway, making it scalable and controlled. It is compatible with aromatic, heteroaromatic, and alkyl aldehydes, producing diverse ketones with high yields (42–95%). Air-stable and base-compatible, it offers an efficient and practical approach to ketone synthesis.

Synonyms: 3-(trifluoromethyl)benzenesulfonyl hydrazide; 3-(trifluoromethyl)benzenesulfonic acid hydrazide; 3-(trifluoromethyl)benzene-1-sulfonohydrazide