More

  • Home
  • Research
  • Publications
  • Novel agonists of free fatty acid receptor 1 (GPR40) based on 3-(1,3,4-thiadiazol-2-yl)propanoic acid scaffold

Synthesis and studies on gem-fluorinated 2-azabicyclo[n.1.0]alkanes

J. Fluorine Chem. 2015, 175 73-83

DOI: 10.1016/j.jfluchem.2015.03.008

Kubyshkin V.; Kheylik Y.; Mykhailiuk P. K.

Three novel amines all possessing gem-difluorocyclopropane, secondary amino group and a fused aliphatic cycle were synthesized by difluorocyclopropanation of N-Boc protected enamides. The compounds were stable when amino group was blocked by protonation or acylation, but otherwise underwent fragmentation already at the room temperature. Chemical structure, physico-chemical properties and fragmentation mechanisms of the fluorinated amines are studied in details.

Synthesis and studies on gem-fluorinated 2-azabicyclo[n.1.0]alkanes

FOLLOW US

Contact us

Send a message