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Bis(2,2,2-trifluoroethyl) Carbonate as a Condensing Agent in One-Pot Parallel Synthesis of Unsymmetrical Aliphatic Ureas

ACS Comb. Sci. , 2014, 16 (6), 303-308

DOI: 10.1021/co500025f

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Granat D. S.; Pipko S. E.; Konovets A. I.; Doroschuk R.; Tolmachev A.

One-pot parallel synthesis of unsymmetrical aliphatic ureas was achieved with bis(2,2,2-trifluoroethyl) carbonate. The procedure worked well for both the monosubstituted and functionalized alkyl amines and required no special conditions (temperature control, order, or rate of addition). A library of 96 diverse ureas was easily synthesized.

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Granat D. S.; Pipko S. E.; Konovets A. I.; Doroschuk R.; Tolmachev A.
ACS Comb. Sci. 2014, 16 (6), 303-308
DOI: 10.1021/co500025f

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