Building Blocks Catalog

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Building Blocks

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2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from February 2024

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    March, 2024, Kyiv, Ukraine. Enamine Ltd, the global leader in supplying small molecules and early drug discovery services, announces the expansion of its library synthesis capabilities with a focus on Enamine REAL compounds to further support the growing demands of agricultural and pharmaceutical companies, research institutes, and drug discovery centers.

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Mol. Diver. , 2012, 16 (4), 625-637

DOI: 10.1007/s11030-012-9407-9

Ryabukhin S.; Panov D.; Plaskon A.; Chuprina A.; Pipko S.; Tolmachev A.; Shivanyuk A.

128 Azomethines were synthesized through condensation of carbonyl compounds with various amines in pyridine in the presence of Me3SiCl as promoter and water scavenger in 58–98 % yield. Et3N was added to reaction mixtures before precipitating the product with H2O to prevent acid catalyzed hydrolysis of the C=N bond. The scope and limitation of the method are discussed. High yields and simple setup/workup procedure make this method suitable for the combinatorial synthesis of azomethines, which are suitable as starting materials for high throughput synthesis of various combinatorial libraries. The azomethines synthesized were used as starting materials in a one-pot combinatorial synthesis of amines and amides.

Combinatorial synthesis of chemical building blocks 1. Azomethines

Ryabukhin S.; Panov D.; Plaskon A.; Chuprina A.; Pipko S.; Tolmachev A.; Shivanyuk A.
Mol. Diver. 2012, 16 (4), 625-637
DOI: 10.1007/s11030-012-9407-9

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