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Recent News
27 March 2024
Press Release
March, 2024, Kyiv, Ukraine. Enamine Ltd, the global leader in supplying small molecules and early drug discovery services, announces the expansion of its library synthesis capabilities with a focus on Enamine REAL compounds to further support the growing demands of agricultural and pharmaceutical companies, research institutes, and drug discovery centers.
01 March 2024
News
We are excited to announce a strategic collaboration between Enamine, the world's leading provider of chemical building blocks, compound libraries, and biology services, and Genez International, a prominent enterprise with 15 years of experience in cross-border supply management, biopharmaceutical research and development, semiconductor equipment, and high-definition digital imaging systems.
21 February 2024
Press Release
Cresset recently announced a collaboration with Enamine, the world’s leading provider of chemical building blocks and drug discovery services to develop innovative new solutions for the early drug discovery process.
Mol. Diver. , 2012, 16 (4), 625-637
DOI: 10.1007/s11030-012-9407-9
Ryabukhin S.; Panov D.; Plaskon A.; Chuprina A.; Pipko S.; Tolmachev A.; Shivanyuk A.
128 Azomethines were synthesized through condensation of carbonyl compounds with various amines in pyridine in the presence of Me3SiCl as promoter and water scavenger in 58–98 % yield. Et3N was added to reaction mixtures before precipitating the product with H2O to prevent acid catalyzed hydrolysis of the C=N bond. The scope and limitation of the method are discussed. High yields and simple setup/workup procedure make this method suitable for the combinatorial synthesis of azomethines, which are suitable as starting materials for high throughput synthesis of various combinatorial libraries. The azomethines synthesized were used as starting materials in a one-pot combinatorial synthesis of amines and amides.
Ryabukhin S.; Panov D.; Plaskon A.; Chuprina A.; Pipko S.; Tolmachev A.; Shivanyuk A.
Mol. Diver. 2012, 16 (4), 625-637
DOI: 10.1007/s11030-012-9407-9