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Recent News
27 March 2024
Press Release
March, 2024, Kyiv, Ukraine. Enamine Ltd, the global leader in supplying small molecules and early drug discovery services, announces the expansion of its library synthesis capabilities with a focus on Enamine REAL compounds to further support the growing demands of agricultural and pharmaceutical companies, research institutes, and drug discovery centers.
01 March 2024
News
We are excited to announce a strategic collaboration between Enamine, the world's leading provider of chemical building blocks, compound libraries, and biology services, and Genez International, a prominent enterprise with 15 years of experience in cross-border supply management, biopharmaceutical research and development, semiconductor equipment, and high-definition digital imaging systems.
21 February 2024
Press Release
Cresset recently announced a collaboration with Enamine, the world’s leading provider of chemical building blocks and drug discovery services to develop innovative new solutions for the early drug discovery process.
Synthesis , 2008, 17, 2701-2706
DOI: 10.1055/s-2008-1067214
Tverdokhlebov A. V.; Andrushko A. P.; Tolmachev A. A.; Shishkina S. V.; Shishkin O. V.
Alkylation of (3,4-dihydro-4-oxo-2H-1,3-benzothiazin-2-ylidene)acetic acid ethyl ester and (3,4-dihydro-4-oxo-2H-1,3-benzothiazin-2-ylidene)acetonitrile with phenacyl chlorides in the presence of potassium carbonate was shown to occur at the nitrogen atom yielding the corresponding N-phenacyl derivatives. The latter, upon treatment with DMF•POCl3 complex, were converted into 1-aroyl-9-oxo-9H-pyrrolo[2,1-b][1,3]benzothiazine-3-carboxylic acid ethyl esters and -3-carbonitriles. The structure of the obtained pyrrolobenzothiazine derivatives was confirmed unambiguously by X-ray crystallographic study. Reaction of these pyrrolo[2,1-b][1,3]benzothiazines with aliphatic primary amines resulted in the thiazine ring cleavage and formation of 2-[(5-aroyl-3-cyano(or ethoxycarbonyl)-1H-pyrrol-2-yl)thio]-N-alkylbenzamides.
Tverdokhlebov A. V.; Andrushko A. P.; Tolmachev A. A.; Shishkina S. V.; Shishkin O. V.
Synthesis 2008, 17, 2701-2706
DOI: 10.1055/s-2008-1067214