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Tetrahedron Lett. , 2011, 52 (12), 1300-1302

DOI: 10.1016/j.tetlet.2011.01.070

Yarmolchuk V. S.; Mykhailiuk P. K.; Komarov I. V.

A synthetic strategy towards the novel amino acid β-fluoro-β-proline, a fluorinated analogue of β-proline, is elaborated. The synthesis commences from commercially available methyl 2-fluoroacrylate and involves three steps. The overall yield of β-fluoro-β-proline is 57%.

Synthesis of β-fluoro-β-proline

Yarmolchuk V. S.; Mykhailiuk P. K.; Komarov I. V.
Tetrahedron Lett. 2011, 52 (12), 1300-1302
DOI: 10.1016/j.tetlet.2011.01.070

 

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