Expedient Synthesis of cis- and trans-3-Aminocyclobutanecarboxylic Acids

Abstract An expedient approach to cis- and trans-3-aminocyclobutanecarboxylic acids was developed starting from 1,1-cyclobutanedicarboxylic acid. Stereochemistry of the title compounds was established by nuclear Overhauser effect spectroscopy experiments. An expedient approach to cis- and trans-3-aminocyclobutanecarboxylic acids was developed starting from 1,1-cyclobutanedicarboxylic acid. Stereochemistry of the title compounds was established by nuclear Overhauser effect spectroscopy experiments.

Radchenko D. S.; Tkachenko A.; Grygorenko O. O.; Komarov I. V.
Synth. Commun. 2011, 41 (11), 1644-1649
DOI: 10.1080/00397911.2010.491595