A Facile Synthesis of 1-Chloro-2,2,2-trifluoroethyl Sulfides

A facile synthesis of structurally diverse 1-chloro-2,2,2-trifluoroethyl sulfides from readily available 1-bromo-1-chloro-2,2,2-trifluoroethane (Halothane®) and various aliphatic and aromatic thiols in the presence of sodium dithionite/sodium bicarbonate is described. The synthetic utility of the prepared sulfides is illustrated by the synthesis of biologically potent heterocycles and by their electrophilic reactions with thiophene.

Pustovit Y.; Alexeenko A.; Trofymchuk S.; Lukin O.; Tolmachev A. A.
Synthesis 2010, 07, 1159-1165
DOI: 10.1055/s-0029-1219232