300 Thousand compounds in stock
Original and unique
Make-on-demand
Building Blocks
1B novel building blocks
Reliable supply
Over 650 highly skillful chemists
Unique synthesis technologies
48B Billion
REAL compounds and
Custom Library Synthesis
On site access to all Enamine stock BB’s
Highly flexible arrangements
2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from February 2024
Recent News
27 March 2024
Press Release
March, 2024, Kyiv, Ukraine. Enamine Ltd, the global leader in supplying small molecules and early drug discovery services, announces the expansion of its library synthesis capabilities with a focus on Enamine REAL compounds to further support the growing demands of agricultural and pharmaceutical companies, research institutes, and drug discovery centers.
01 March 2024
News
We are excited to announce a strategic collaboration between Enamine, the world's leading provider of chemical building blocks, compound libraries, and biology services, and Genez International, a prominent enterprise with 15 years of experience in cross-border supply management, biopharmaceutical research and development, semiconductor equipment, and high-definition digital imaging systems.
21 February 2024
Press Release
Cresset recently announced a collaboration with Enamine, the world’s leading provider of chemical building blocks and drug discovery services to develop innovative new solutions for the early drug discovery process.
ACS Omega
2019, 4 (1), 203-213
DOI:
10.1021/acsomega.8b02595
Dorofeeva V.; Pavlishchuk A.; Kiskin M.; Efimov N.; Minin V.; Lytvynenko A.; Gavrilenko K.; Kolotilov S.; Novotortsev V.; Eremenko I.
Interaction of a tripyridine ligand bearing a 2,6-di-tert-butylphenolic fragment (L, 2,6-di-tert-butyl-4-(3,5-bis(4-pyridyl)pyridyl)phenol) with CoII pivalate or chloride led to the formation of one-dimensional coordination polymers [Co(L)Cl2]n·nEtOH (1) and [Co3(L)2(OH)(Piv)5]n (2) or a trinuclear complex Co3(H2O)4(L)2Cl6 (3) (Piv– = pivalate). Chemical oxidation of L and 1–3 by PbO2 or K3[Fe(CN)6], as well as exposure of L (in solution or solid state) and 2 (in solid state) to UV irradiation, led to the formation of free radicals with g = 2.0024, which probably originated because of oxidation of 2,6-di-tert-butylphenolic groups. These radicals were stable for several days in solutions and more than 1 month in solid samples. Irradiation and oxidation of the solid samples probably caused formation of the phenoxyl radical only on their surface. It was shown by density functional theory calculations that exchange coupling between the unpaired electron of the phenoxyl radical and CoII ions was negligibly weak and could not affect the electron paramagnetic resonance signal of the radical, as well as exchange coupling of CoII ions could not be transmitted by L. The latter conclusion was confirmed by the analysis of magnetic properties of 1: temperature dependency of magnetic susceptibility (χM) of 1 could be simulated by a simple model for isolated CoII ions.