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Cysteine focused Covalent Fragments

The library of Cys-specific covalent electrophilic binders

3 200 compounds

Covalent chemical probes become an important tool in drug discovery within last few years. The impressive number of successful applications in protein drugability assessment, especially focusing on Cys residue, brought aspiration to discovery and synthesis of new covalent modifiers.

We used deep knowledge-based approach to design and synthesize our cysteine focused fragment library. Careful choice of covalent warheads based on their reactivity was performed by experienced chemists and reflected a small set of specific structural filters. Electrophilic fragments selected by structural filters were then analyzed to remove any molecules with trivial or unwanted structural features.

Most popular Library Formats

Catalog ID
Compounds
Amount
Format
Price

Catalog ID

CYS-3200-10-Y-100

Compounds

3 200
10 plates

Amount

10 µL of 100 mM DMSO stock solutions

Plates and formats

384-well microplates, Echo qualified Labcyte, 320 compounds per plate

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Catalog ID

CYS-3200-25-Y-20

Compounds

3 200
10 plates

Amount

25 µL of 20 mM DMSO stock solutions

Plates and formats

384-well plates, Greiner Cat. No. 781280, 1, 2 and 23, 24 columns empty, 320 compounds per plate

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Catalog ID

CYS-3200-50-X-20

Compounds

3 200
40 plates

Amount

50 µL of 20 mM DMSO stock solutions

Plates and formats

96-well plates, 2D-barcoded Matrix microtubes capped with sepraseals

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Hits derived from this library can be easily followed with analogues from stock or either synthesis of new compounds through REAL Database technology.

Selected covalent warheads

  • Acrylamides
  • Chloroacetamides
  • Cyanacrylamides
  • Disulfides
  • Maleimides
  • Acyl chorides

Examples of the molecules

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